SMARCA4 and lung carcinoma: Indeed, both BRG1 or MITF depletion severely reduced proliferation of 501mel cells, whereas the growth of BRG1/BRM non-expressing A427 lung carcinoma cells (used as a control to exclude a possible off target effects of sh-BRG1) was not inhibited, indicating that the effect of sh-BRG1 plasmid was specific (Figure 1B, upper, left).