It is noteworthy that the single primary variable showing an inverse correlate of infection risk in the RV144 case-control study was Ab reactivity with gp70-V1V2 which contains the V1V2 sequence of case A2, a subtype B strain [20] which carries both the V169 and the E172 residues that reduce reactivity of vaccinees' Abs with V2 peptides (Figure 5B). The gene discussed is EMB; the disease is infection.