Recent studies have shown that signaling pathways and their associated molecules play complex and pivotal roles in the development of cardiac hypertrophy,including mitogen activated protein kinases (MAPKs), phosphatidylinositol 3-kinase(PI3K)/AKT and calcineurin/nuclear factor of activated T cells (NFAT) [10]. Here, WNK2 is linked to cardiac hypertrophy.