To investigate whether Wnt5a has a potential role during the early stage of lung cancer development by cigarette smoking, we first profiled Wnt5a mRNA and protein expressions in five HBE cells (NHBE, BEAS-2B, 1179, 1198 and 1170I) at different malignant stages established by exposing them to CSC (Table 1) [16], [17]. This evidence concerns the gene WNT5A and lung cancer.