However, this study analyzed SNPs in CAPN-10 because these have been associated with T2DM in the Mexican population [23] and calpain-10 participates in both glucose-stimulated insulin secretion in beta-cells [25] and in insulin-stimulated GLUT4 translocation to the plasma membrane in adipocytes [26]. This evidence concerns the gene CAPN10 and type 2 diabetes mellitus.