INS and Insulin resistance: SNP-43 in CAPN-10 is involved in many of the phenotypes associated with T2DM, such as insulin resistance, lipogenesis, insulin secretion and microvascular function [41], [42], [43], [44], while SNP-44 has been associated with increase risk for T2DM in Mexican population [23] and with other populations as evaluated through meta-analysis [24].