Because genetics and environment, as well as their interaction, play a crucial roles in T2DM onset [28], the data were analyzed taking into account risk polymorphisms in CAPN-10 conferring risk for T2DM in Mexican-American and Mestizo-Mexican populations: SNP-43 (rs3792267), Indel-19 (rs3842570), SNP-63 (rs5030952) and SNP-44 (rs2975760) [22], [23]. Here, CAPN10 is linked to type 2 diabetes mellitus.