In stage-1, we analyzed 944 cases of lymphoma, including 275 FL, and 4044 controls and documented strong evidence of association between SNPs on Chr6, with at least 9 SNPs showing PFL<1×10−7 at the HLA region (chr6:32.17–32.89 Mb) encompassing genes TNXB to HLA-DOB. The gene discussed is TNXB; the disease is lymphoma.