Numerous mutations in the VCP gene have been linked with genetic disorders such as Inclusion Body Myopathy with Paget's disease of bone and Fronto-temporal Dementia (IBMPFD) and familial Amyotrophic Lateral Sclerosis (ALS) [47], [48]. This evidence concerns the gene VCP and inclusion body myopathy with Paget disease of bone and frontotemporal dementia.