CD4+ T-cell mediated I-cell driven hypophagia during enteritis was seen to result in significant weight loss at days 8 and 12 p.i., accompanied by a visible reduction in abdominal fat pads, whereas the brief TNFα driven secondary hypophagia produced no significant alteration in weight at day 20 p.i. (Fig. 4a). Here, CD4 is linked to enteritis.