TERF2 and familial dilated cardiomyopathy: Furthermore, our findings revealed that the mimetic treatment normalized the molecular changes due to DCM, such as those in connexin43, telomerase reverse transcriptase (mTERT), telomeric repeat binding factor 2 (TRF2), phospho-AKT, insulin-like growth factor (IGF-1), endothelial nitric oxide synthase (eNOS), SIRT1, and FOXO3a [25,26].