Cryptosphaerolide was found to be an inhibitor of the protein Mcl-1(induced myeloid leukemia cell differentiation protein), a cancer drug target involved in apoptosis in HCT-116 human colon carcinoma cell line, indicating that the compound may be of value in exploring the Mcl-1 as a target for cancer chemotherapy [110]. The gene discussed is MCL1; the disease is colon carcinoma.