Amongst targeted agents which inhibit osteoclast activity and are currently subject to clinical evaluation in breast cancer bone metastases are inhibitors to mTOR, RANKL, Src and Cathepsin K. A recent clinical trial administrating the mTOR inhibitor Everolmus, a rapamycin derivative which inhibits mTORC1, showed beneficial effects on bone turnover and bone progression in postmenopausal women with oestrogen-receptor-positive breast cancer [52]. The gene discussed is TNFSF11; the disease is breast cancer.