To rationalize why CD1c/CD1d modulation is not more significantly enhanced during HIV-1 infection and understand the role cholesterol production may play in CD1c/CD1d expression during infection, we blocked cholesterol production in the HIV-1-infected cells by incubating the cells with 10 μM simvastatin, an enzyme that inhibits the cholesterol biosynthesis pathway. Here, CD1C is linked to HIV-1 infection.