This prospective study with baseline and eight-week- post controlled caloric excess measurements tests our hypothesis that significantly expanded visceral adipose tissue [increased body mass index and waist circumference], increases adipose cell size [signifying adipose tissue dysfunction], potentiates systemic inflammation [increased C reactive protein, leptin] and worsens insulin resistance [elevated fasting plasma glucose, fasting insulin, and Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR)] in healthy adults. This evidence concerns the gene CRP and Insulin resistance.