It has been put forward that loss of M6P/IGF2Rmay promote the invasiveness of malignant tumour cells [24].Various studies have shown that M6P/IGF2R indeed has the capacity to impede tumour cell migration[25,26].Interestingly, we have recently found that M6P/IGF2R modulates the invasiveness of liver cells viaits capacity to bind M6P-modified proteins [27]. Here, IGF2R is linked to neoplasm.