M6P/IGF2R Dom11mut was found to be lessgrowth-inhibitory than the wt receptor under standard culture conditions, in line with studiesperformed on LNCaP and PC-3 human prostate cancer cells [41].However, this M6P/IGF2R mutant is still capable of restricting anchorage-independent growth ofSCC-VII cells. This evidence concerns the gene IGF2R and Familial prostate cancer.