In contrast, the alleviation of airway disease was found to be related to a suppression of Th2, proinflammatory, and Th17 cytokines in splenocytes and to an inhibition of specific IgE production in serum; these changes lead to a reduction in the AHR to methacholine and a reduction in lung inflammation in OVA-allergic asthma mice. This evidence concerns the gene IGHE and allergic asthma.