CYP2E1 and metabolic dysfunction-associated steatotic liver disease: Observations in a NAFLD pediatric population have indicated a direct correlation between lipid peroxidation and disease severity irrespective of CYP2E1 levels; however, the small sample size of this study and the possibility of alternative mechanisms of lipid peroxidation in early onset hepatic steatosis cannot be excluded (Bell et al., 2011).