Mice with silenced diacylglycerol acyltransferase 2 (Dgat2) on MCD diet display elevated Cyp2e1 expression that correlates with increased lipid peroxidation and oxidative damage, thus highlighting the role of CYP2E1 in the progression to NASH in response to increased hepatic free fatty acids (Yamaguchi et al., 2007). Here, CYP2E1 is linked to metabolic dysfunction-associated steatohepatitis.