SLC22A8 and metabolic dysfunction-associated steatohepatitis: Studies in rat and human samples have indicated a coordinated downregulation of uptake transporter genes in NASH, such as the sodium/bile acid transporter (NTCP), organic anion transporting polypeptide 1a1 (OATP1a1), 1a4, 1b2, 2b1, OAT2, and OAT3. The expression of these transporters is significantly altered in the transition from steatosis to NASH rather than between control and steatotic samples (Fisher et al., 2009a; Lake et al., 2011).