NOS2 and metabolic dysfunction-associated steatohepatitis: Car+/+ mice fed with MCD diet, known to induce NASH (Rinella et al., 2008), developed enhanced liver fibrosis due to lipid peroxidation, inducible nitric oxide synthase (iNOS), and increased CYP induction compared to Car−/− mice (Yamazaki et al., 2007).