The most recent work on the subject, by Regan et al. (2012), enrolled a large number of postmenopausal patients treated with tamoxifen for 5 years, as part of the BIG 1–98 trial, and showed no association between CYP2D6 metabolizing phenotype and the risk of recurrence (characterized by the breast cancer-free interval), with or without previous chemotherapy. The gene discussed is CYP2D6; the disease is breast carcinoma.