In the periphery and CNS, altered cytokine profiles (e.g., TNF-α, IFN-γ, IL-17, IL-6, and IL-18) contribute to the pathological features of MS, such as demyelination, loss of oligodendrocytes, and axonal degeneration (Lucchinetti et al., 2000; Bjartmar et al., 2003; Imitola et al., 2005). The gene discussed is IL17A; the disease is myeloid sarcoma.