In a study in PD, MSA, CBD, PSP, and healthy controls, a panel of four proteins (ubiquitin, β2-microglobulin, and 2 secretogranin 1 [chromogranin B] fragments) was identified which could differentiate PD and healthy controls on one side from APD on the other side with an AUC of 0.8 (Constantinescu et al., 2010a). The gene discussed is CHGB; the disease is Parkinson disease.