Five of the identified genes induce a roughly typical PD presentation [a-synuclein, parkin, PTEN induced putative kinase 1, DJ-1, and leucine-rich repeat kinase 2 (LRRK2)] while mutations of ATP13A2 (PARK9) cause Kufor–Rakeb disease characterized by both Parkinsonism and many atypical features (Coppede, 2012). This evidence concerns the gene SNCA and Parkinson disease.