Recently, we have reported that overexpression of BECN1, administration of cystamine, or depletion of SQSTM1 by RNA interference, can favor the trafficking of F508del-CFTR protein to the epithelial cell surface in vitro in CF epithelial cell lines (CFBE41o- or IB3-1, carrying F508del/F508del or F508del/W1282X CFTR, respectively), ex vivo in nasal polyp biopsies from CF patients, and in vivo in CftrF508del mice. This evidence concerns the gene BECN1 and cystic fibrosis.