CFTR and cystic fibrosis: These findings could also explain how cystamine, which is not an autophagy inducer, is highly effective in restoring autophagy within a “CF environment.” The fact that cystamine can regulate peripheral proteostasis is also supported by the observation that cystamine (but not CFTR correctors as VX-325 or Corr-4a) is effective in sustaining PM stability of F508del-CFTR even if it has previously been rescued at the PM by low temperature.