SQSTM1 and cystic fibrosis: Autophagy deficient CF cells accumulate SQSTM1 (p62), an ubiquitin-binding (and LC3-binding) protein (Bjørkøy et al., 2005; Kirkin et al., 2009; Mathew et al., 2009; Duran et al., 2011) that is selectively degraded by autophagy.