In the following, we will evaluate this exemplarily by considering selected variations in CYP enzyme activities (CYP3A4 activities of 0.95 and 1.9 μM/min and CYP2E1 activities of 1.0 and 5.0 μM/min (Bolt et al., 2003); the selection of the CYP2E1 is made in order to represent alcoholism and non-alcoholism) and by analyzing the distribution of substances as well as cell viability in the organ. The gene discussed is PPIG; the disease is alcohol dependence.