Following ischemia and traumatic brain injury, expression of various growth factors such as epidermal growth factor (EGF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), fibroblast growth factor 2 (FGF2), glial cell line-derived neurotrophic factor (GDNF), insulin-like growth factor 1 (IGF-1), pituitary adenylate cyclase-activating polypeptide (PACAP), and vascular endothelial growth factor (VEGF) are increased and modulate neurogenesis and NSPC biology. Here, ADCYAP1 is linked to ischemia.