FAS and acute respiratory distress syndrome: On the other hand, even without specific target cell delivery systems, animal studies modeling ARDS have shown promising beneficial effects on survival and histopathological changes by using a number of systemic or intratracheal apoptosis-based treatments, including blockade of FasL by decoy receptor-3 [80], Fas:Ig fusion protein [81] or Fas-siRNA [82] and pan-caspase inhibition by z-VAD-fmk [83].