As we briefly anticipated earlier in this review, the RUNX1-ETO fusion protein generated in t(8;21)-positive AML directly downregulates miR-223 through recruitment of histone deacetylases (HDACs) and DNA methyl transferases (DNMTs), which impose repressive chromatin changes in the miR-223 promoter [127]. Here, RUNX1T1 is linked to acute myeloid leukemia.