The ATP2C1/ASTE1 partial overlap (Figure 1C, arrowheads) could represent a human-specific regulatory mechanism; when ASTE1 is mutated (e.g., in human colorectal cancers [15]) the SPCA1 protein could accumulate, potentially leading to secretory pathway abnormalities and eventually neoplastic transformation. The gene discussed is ATP2C1; the disease is colorectal cancer.