Thus, a large-scale MLPA exploration of 1506 German families for pathogenic genomic rearrangements in the BRCA1 gene and of 450 families for gross rearrangements in BRCA2 showed that in high-risk groups for hereditary breast and ovarian cancer, the prevalence of rearrangements was 2.1% [108]. Here, BRCA1 is linked to ovarian cancer.