For instance, Iyoda et al. [45] found that the renal pathology in cryoglobulin-associated membranoproliferative glomerulonephritis mice (mice overexpressing thymic stromal lymphopoietin [TSLP]) was aggravated after treatment with ATRA (20 mg/kg 3 times weekly by intraperitoneal injection), and significantly increased glomerular collagen IV in cryoglobulin-associated membranoproliferative glomerulonephritis mice at 4 weeks but not 8 weeks. The gene discussed is TSLP; the disease is membranoproliferative glomerulonephritis.