TIMP1 and Hepatic fibrosis: The expression of type I collagen (COL-I), tissue inhibitors of metalloproteinase-1 (TIMP-1), TGF-β1, and connective tissue growth factor (CTGF) were reduced, whilst He H et al. [18] reported that 5 mg/kg ATRA significantly reduced liver fibrosis and nearly eliminated liver necrosis after CBDL in male Sprague-Dawley rats, especially in combination with ursodeoxycholic acid (UDCA).