Equally, Yang KL et al. [16] reported that a RA derivative isolated from the mycelium of Phellinus linteus could antagonize ECM accumulation and liver fibrosis in BALB/c mice by down-regulating reactive oxygen species (ROS) generation and calcium influx, thereby directly affecting transforming growth factor-β1 (TGF-β1). The gene discussed is TGFB1; the disease is Hepatic fibrosis.