Inasmuch, an association between the rs9282861 homozygous variant AA genotype of sulfotransferase 1A1 (SULT1A1, involved in detoxification of 4-hydroxytamoxifen), and overall long-term survival of breast cancer patients treated with adjuvant tamoxifen, has been described [246]. The gene discussed is SULT1A1; the disease is breast carcinoma.