FLT4 and prostate neoplasm: Another study showed that in subcutaneous and orthotopic human prostate tumor xenograft models, abrogation of VEGFR3 signaling significantly inhibited lymph node metastasis, but not growth of the prostatic tumor, whereas blockade of VEGFR-2 signaling efficiently repressed tumor blood vessel density and tumor growth without a corresponding reduction in nodal metastasis [119].