Coordinated expression of VEGF-C and VEGFR-3 in patients with non-small cell lung cancer (NSCLC) is an important influential factor in lymphatic metastasis; moreover, VEGF-C is expressed mainly in cancer cells and its receptor VEGFR-3 is predominantly localized in endothelial cells [88]. This evidence concerns the gene FLT4 and non-small cell lung carcinoma.