SRC and neuroendocrine neoplasm: The relevance of SFKs in neuroendocrine tumors has also been underlined by the recent finding that neuroendocrine cancer stem cells (N-CSC), present strong activity of both the Src and mTOR pathways, and that targeting Src inhibits the growth both of N-CSCs cells in vitro, and of tumors derived from them in vivo [59].