RUNX1 and ERG were hypothesized as candidates for leukemia in non-DS patients; however, triplicate dosages of these two genes were incapable to generate transient myeloproliferative leukemia in Ts1Cje mice and thus, these two genes may not be directly responsible for development of leukemia in individuals with DS [62]. This evidence concerns the gene RUNX1 and leukemia.