We show that the combination of dovitinib with the PI3K/mTOR inhibitor, NVP-BEZ235 [10], strongly downregulates the FRS2/extracellular signal-regulated kinase (Erk) and PI3K/Akt/mTOR signaling pathways, resulting in high levels of apoptosis and tumor stasis. This evidence concerns the gene FRS2 and neoplasm.