Testing the pan-ErbB inhibitor AEE788 [11] in the 4T1 and 67NR models revealed that only the combination of AEE788 and dovitinib resulted in blockade of the FRS2/Erk and PI3K/Akt/mTOR pathways, high levels of apoptosis with prolonged tumor stasis, and in the 4T1 model a highly significant decrease in lung metastasis. This evidence concerns the gene FRS2 and neoplasm.