NFKB1 and colorectal carcinoma: For instance, Fernández-Majada et al. reported that the increased IKK activity in colorectal cancer (CRC) cell lines and primary CRC is concomitant with undetectable levels of nuclear p65 and p52, which is consistent with the absence of p65 and p52 on different promoters of NFκB-target genes detected by ChIP analysis.