Aside from nuclear regulation of NF-κB-dependent gene transcription through chromatin modification in response to pro-inflammatory stimuli, nuclear IKKα also functions in apoptosis, cell cycle, and tumor progression in colorectal [17,18], breast [19,20], pancreatic [21], gastric [22], osteosarcoma [23], and prostate [24] cancers. The gene discussed is CHUK; the disease is osteosarcoma.