The decreased adhesion observed in p38α silenced K562 cells point out to a positive regulation of CML adhesion by p38α, according to the role proposed for p38 in adhesion in human melanoma cells[60] and in Karpas 299 lymphoma cells based on the effect of the p38α/ß inhibitor SB203580[61]. This evidence concerns the gene CRK and chronic myelogenous leukemia, BCR-ABL1 positive.