Also, in agreement with previous findings, a direct, although weak, interaction between the Cbl-SH3-b domain and the CrkL-SH3 (CrkL-D1) domain was observed[41], although in CML cells Cbl interacts preferentially with the CrkL-SH2 domain[24]. This evidence concerns the gene CBL and chronic myelogenous leukemia, BCR-ABL1 positive.