The role of the adapter proteins CrkL, p130Cas and Cbl in CML is well documented[1,12,23,24], and the association between Cbl and C3G, through CrkL, has been described in CML cells, fibroblasts, NK cells and T-cells[11,25-28]. This evidence concerns the gene RAPGEF1 and chronic myelogenous leukemia, BCR-ABL1 positive.