The direct interaction between p130Cas-P2 and CrkL-SH3 domain (CRKL-D1) contrasts with previous reports showing a direct association between CrkL and p130Cas through the CrkL-SH2 domain in Bcr-Abl expressing cells and CML patients[12]. This evidence concerns the gene CRKL and chronic myelogenous leukemia, BCR-ABL1 positive.