In this regard, the work of Gershon et al. [2] on hexokinase-2 (HK2)-mediated aerobic glycolysis during cerebellar neurogenesis and the pathogenesis of medulloblastoma is significant, both as an in vivo confirmation of an important role for HK2-driven aerobic glycolysis in tumorigenesis, and in demonstrating a role for aerobic glycolysis in normal development. Here, HK2 is linked to medulloblastoma.