Specifically, mCMV-induced SG dysplasia/neoplasia is characterized by (1) mesenchymal-to-epithelial transformation (MET); (2) epithelial islands comprised of hyperplastic, dysplastic and neoplastic cells; (3) an admixing of basophilic stromal and abnormal epithelial cells; (4) migration of epithelial cells into dilated ductal lumina; (5) de novo re-expression of CREB-regulated transcription coactivator 1 (CRTC1) protein, a protein found in SG MECs but not in normal SG tissue [7]; and (6) an upregulation of the activated COX/AREG/EGFR/ERK signaling pathway. Here, EGFR is linked to neoplasm.