In this context Iwata et al. analyzed whether there is an association between ABCB11 or NR1H4 (FXR, the gene activator of BSEP) polymorphisms and fibrosis progression [89].The “cholestatic” ABCB11 1331C allele and corresponding CC genotype was associated with the presence of cirrhosis in a HCV‐infected study population. The gene discussed is NR1H4; the disease is Cirrhosis.