It has been hypothesized that hyperglycemia could promote perineural invasion in pancreatic cancer through two mechanisms: (1) enhanced cell proliferation and increased expression of cytokines such as nerve growth factors (NGFs) and enhanced interactions of nerve and cancer cells; (2) demyelinization and axonal degeneration of nerves, which facilitate cancer cells' invasion to the nerves [8]. Here, NGF is linked to pancreatic neoplasm.