BCL2 and neoplasm: The role of CXCL-8 in regulating antiapoptotic genes in melanoma has not been studied here, but it has been reported in androgen-independent prostate cancer cells, where Bcl-2 and inhibitors of apoptosis (IAP) family gene transcripts were upregulated via NF-κB activation stimulated by CXCL-8, thus rendering tumor cells more resistant to the cytotoxic oxaliplatin treatment [29].