TGFB1 and neoplasm: Moreover, the paracrine route of exosomal TGF-β can also be related to the modulation of the extracellular matrix and emergence of fibrotic tissue that always accompanied the invading tumor islands and that separated them from the bundles of smooth muscles of the myoma, possibly indicating that exosomal TGF-β can regulate fibrogenesis in order to facilitate tumor migration and invasion [31, 32].