When the current Stockholm cohort was dichotomized based on Gleason score, we observed that Wnt5a expression level was significantly associated with outcome in PCa patients with low-grade cancers as patients in this group with high-Wnt5a protein expression had significantly longer BCR-free time after RP compared to patients with low-Wnt5a expression (P = 0.017; Fig. 2A). Here, BCR is linked to posterior cortical atrophy.