We demonstrate that IL-1β induced the expression of the secreted MMPs: MMP-1 (Collagenase-1), MMP-3 (Stromelysin-1), MMP-10 (Stromelysin-2), and the transmembrane MMP, MT1-MMP (MMP-14), in RCC cells. The gene discussed is MMP14; the disease is renal cell carcinoma.