The accuracy, sensitivity, and specificity for NSCLC detection by the 11-plasma miRNA panel are 87.9%, 85% and 82.9%, respectively, which are higher to those of blood-based single biomarker, such as CYFRA 21-1 (AUC≈0.84, sensitivity≈50%, specificity≈95%), tissue polypeptide specific antigen (AUC≈0.74, sensitivity≈34%, specificity≈95%), and CEA (AUC≈0.8, sensitivity≈53%, specificity≈95%) [33]. The gene discussed is CEACAM5; the disease is non-small cell lung carcinoma.