Additional studies are also warranted to determine the role of the GC-rich region and 5′UTR in the increased translation of HIF1α in prostate cancer cells, especially when enhanced protein synthesis from a specific subset of mRNAs that contain highly structured (GC-rich) 5′UTRs is one of the hallmarks of cancer [51], [52], [53]. Here, HIF1A is linked to prostate carcinoma.