Vergis and co-workers recently reported a significant association between cytoplasmic HIF1α levels in prostate tumors and time to biochemical recurrence in a cohort of prostate cancer patients treated with radiotherapy or radical prostatectomy [27], while Yasuda and co-workers demonstrated that HIF1α expression increases relative risk of recurrence of prostate adenocarcinoma [31]. This evidence concerns the gene HIF1A and prostate adenocarcinoma.