ESR1 and breast cancer: The first study identified, among others, the loci of 17q12 and 17q21.33-q25.1 [28], whereas a hypothesis-generating study from 2012 of 2,000 breast cancer samples identified the loci of 17q23/q20 (in an intermediate prognosis group of predominantly ER+ tumors) and 11q13/14 (in an ER+-subgroup with elevated mortality hazard ratios) [29].