ADIPOQ and metabolic disease: Genetic studies showed that adiponectin polymorphism, SNPs 45T to G and 276G to T are related to obesity in humans [42] and the G/G genotype for SNP276 was associated with lower serum adiponectin levels and waist-to-hip ratio [43], novel genetic determinents of adiponectin levels were identified in 2012 and the identified loci were proved to impact upon metabolic diseases [44].