Owing to our previous finding that ADAM9 is a stress-responsive protein that may support prostate cancer cell survival and progression under intense oxidative stress conditions [13], [19], we sought to determine whether serum starvation, an in vitro condition that mimics the hostile tumor microenvironment [16], [19], can induce the intracellular oxidative stress in which ADAM9-deficient cells failed to overcome. This evidence concerns the gene ADAM9 and prostate carcinoma.