EPHB1 and neuropathic pain: Whereas in the hippocampus LTP is mainly dependent on EphB2, we suggested that in the spinal cord the primary receptor involved in chronic pain would be EphB1 [7], an hypothesis strongly supported by subsequent studies on EphB1 knockout (EphB1 KO) mice, which reported a lack of thermal hyperalgesia in KO mice in a model of neuropathic pain [25] and showed that EphB1 is essential for the generation of LTP between C-fibres afferents and dorsal horn neurons [26].