NFE2L2 and Hepatic fibrosis: And Xu WH suggested that activation of Nrf2 may be also a novel strategy to prevent or ameliorate toxin-induced liver injury and liver fibrosis, demonstrated that Nrf2 can protect liver from ROS damage by regulating the Nrf2 target genes in hepatocytes, which encode enzymes involved in the detoxification of CCl4 and its metabolite, such as GST, NQO1 and GCLC [18].