CCKAR and schizophrenia: While subsequent studies indicated that dysregulation in the dopaminergic system is not necessarily the neurochemical cause of schizophrenia, dopamine is the neurotransmitter operating the neuronal pathway that underlies positive schizophrenia symptoms [30], and indeed CCKAR had been linked to schizophrenia risk and especially positive psychotic symptoms [18] as well as the experience of auditory hallucinations [17], [31].